Abstract A052: Trans-ancestry Validation of a European-Derived Polygenic Risk Score for Statin Response in Young Korean Ischemic Stroke Patients: Results from the GENE_YAS Study

Stroke 2026

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Authors: Eung-Joon Lee, Yeonju Yu, Lee Jc, Jonguk Kim, Nakhoon Kim, Do Yeon Kim, Jihoon Kang, Beom Joon Kim, Han Moon-Ku, Jun Yup Kim, Kangho Choi, Joon-Tae Kim
+44 more Hyunsoo Kim, Man‐Seok Park, Hee-Yun Chae, Kyu Sun Yum, Dong‐Ick Shin, Jung Hwa Seo, Dae Hyun Kim, Jae‐Kwan Cha, Dong‐Seok Gwak, Dong-Eog Kim, J. Y. Park, Kyusik Kang, M. G. LEE, Mi-Sun Oh, Byung‐Chul Lee, Hong-Kyun Park, Yong Jin Cho, Keun‐Sik Hong, Chul‐Hoo Kang, Joonggoo Kim, Jay Chol Choi, Hyungjong Park, Jeong‐Ho Hong, Sung‐Il Sohn, Tai Park, S H Park, Jin-Kyo Choi, Wook‐Joo Kim, Jee‐Hyun Kwon, JEONGYOON LEE, Kyungbok Lee, Lee Jc, Kyungmi Oh, Chi Kyung Kim, Jung Hoon Han, Keon‐Joo Lee, Hae-Bong Jeong, Kwang‐Yeol Park, Lee Jc, Hoonji Oh, Joohon Sung, Soo-Ji Lee, Jeeeun Kim, Hee‐Joon Bae
DOI: 10.1161/str.57.suppl_1.a052
Cited by: 0

Abstract

Background&Purpose: Polygenic risk scores (PRSs) for statin-induced low-density lipoprotein cholesterol (LDL-C) response have been developed in European cohorts, but their utility in non-European populations remains uncertain. We investigated the transferability of a European-derived LDL-C PRS to Korean patients with early-onset ischemic stroke. Methods: We analyzed 2,730 patients aged

Fields of Study & Subjects

Lipoproteins and Cardiovascular Health Genetic Associations and Epidemiology Paraoxonase enzyme and polymorphisms

Publication details

Journal / source
Stroke
Volume
57
Issue
Suppl_1
Publication date
29 January 2026
Language
EN