Abstract A091: Decoding the Etiology of Embolic Ischemic Stroke through Integrated Genomic, Proteomic and Single-cell Transcriptomic Analyses

Stroke 2026

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Authors: Daniela B. Renedo, Cyprien A. Rivier, Shufan Huo, Nanthiya Sujijantarat, Andrew B. Koo, Ryan Matthew Hebert, Kevin Navin Sheth, Dhasakumar S. Navaratnam, Lauren Hachmann Sansing, Guido J. Falcone, Charles Christian Matouk
DOI: 10.1161/str.57.suppl_1.a091
Cited by: 0

Abstract

Background: Understanding the molecular differences between embolic strokes caused by cardioembolism versus atheroembolism is key for identifying therapeutic targets and advancing precision medicine. We applied multiomics and integrative analyses to identify circulating proteins distinguishing atrial fibrillation (AF) from carotid atherosclerosis (CA) in large vessel occlusion strokes. Methods: We first analyzed the plasma proteome of UK Biobank ischemic stroke patients with AF (n=539) versus CA (n=127), comparing levels of 2,923 proteins (Olink platform; FDR

Fields of Study & Subjects

Acute Ischemic Stroke Management Blood Coagulation and Thrombosis Mechanisms Blood properties and coagulation

Publication details

Journal / source
Stroke
Volume
57
Issue
Suppl_1
Publication date
29 January 2026
Language
EN