Abstract A094: Circulating Proteins and microRNAs in E4FAD Mice and Humans as Biomarkers of Cerebral Microbleeds

Introduction: Cerebral microbleeds (CMBs) are age-related manifestations of microangiopathies, predisposing patients to stroke and cognitive dysfunction. Current imaging standards for CMB diagnosis show low sensitivity and specificity and future CMB sequelae often involve brain regions uninvolved by the lesions. Thus, CMBs are indicators of broader brain disease, and early detection of processes associated with CMBs may identify patients at higher risk of future neurological sequelae. This study assesses circulating proteins and miRNAs in patients and E4FAD mice with CMBs compared to non-CMB controls. Methods: The plasma miRNome was assessed in 6 E4FAD mice and 10 CMB patients and in age and sex matched controls. Putative targets for differently expressed (DE) miRNAs were identified in the respective CMB transcriptomes (p