Abstract DP019: Early Therapy Intensity Level is Associated with 1 Year Modified Rankin Scale after Intracerebral Hemorrhage: A MISTIE-III Secondary Analysis

Objectives: Acute care bundles have reduced morbidity and mortality after intracerebral hemorrhage (ICH), but the optimal bundle composition and the timing of its use remain unclear especially in surgically treated ICH. We developed a Therapy Intensity Level (TIL) score, an unweighted composite of seven physiological risk factors previously linked to poorer ICH outcomes and assessed its association with 1-year functional outcome using the MISTIE-III trial of minimally invasive surgery for supratentorial ICH. Methods: The TIL score was derived from pre-specified trial variables and included points for uncontrolled hypertension, hypotension, hyperglycemia, hyperpyrexia, elevated INR, raised intracranial pressure, and cerebral herniation. We calculated TIL scores at baseline and at day 7 for 499 and 473 patients, respectively from the MISTIE-III cohort with available data. Partial proportional odds regression analysis was performed between TIL score and 1-year modified Rankin scale (mRS) adjusting for end of treatment hematoma volume