Abstract DP059: Incidence and Clinical Characteristics of Cervical Artery Dissection Following Chiropractic Cervical Manipulation: A Sub-Analysis of the STOP-CAD Study

Background: Cervical artery dissection (CeAD) is an important cause of stroke in young adults. Some studies reported that nearly 100 million cervical chiropractic manipulations occur in the US annually. The relationship between chiropractic cervical manipulation and CeAD remains a matter of debate, with few large-scale studies examining incidence and clinical characteristics. Methods: We analyzed patients in the multi-center STOP-CAD registry (n=4,023) to identify CeAD cases diagnosed after chiropractic cervical manipulation. Demographics and clinical features were compared between CeAD with vs. without antecedent chiropractic manipulation using chi-square tests and t-tests. We built a multivariable binary logistic regression model that included factors associated with preceding chiropractic manipulation in univariate analyses i.e. those with p