Abstract DP265: Association Between Mental Health Disorders and Anticoagulation Adherence in Patients with Non-Valvular Atrial Fibrillation (NVAF) in Kaiser Permanente Southern California Patients

Introduction: Non-valvular atrial fibrillation (NVAF) increases ischemic stroke risk, making anticoagulation adherence critical. The effectiveness of direct oral anticoagulants (DOACs) and warfarin depends on consistent adherence. Although depression has been linked to lower anticoagulant adherence, the impact of other psychiatric disorders is less understood. We evaluated the association between mood and psychotic disorders and anticoagulation adherence among NVAF patients in a Southern California integrated health system. Methods: We retrospectively collected data from 15 hospitals between January 1, 2017, and December 31, 2022. Baseline demographic data, vascular risk factors, anticoagulation type and mental health disorders were gathered. Anticoagulation adherence was quantified using proportion of days covered (PDC) and categorized as nonadherent (