Abstract DP280: Recurrence After a First Cerebral Venous Thrombosis: Pooled Risks of Recurrent CVT, Other VTE, and Mortality — Systematic Review and Meta-analysis

Introduction: Cerebral venous thrombosis (CVT) generally has favorable outcomes, yet the risk of recurrence and other venous thrombotic events (VTE) remains a critical concern for long-term management. Accurate pooled estimates are essential to guide secondary prevention strategies and the duration of anticoagulation. Objective: To quantify pooled risks of recurrent CVT, other VTE, and all-cause mortality after a first CVT and to compare outcomes by anticoagulant class. Methods: We conducted a systematic search was performed from inception to March 2025. Eligible studies reported post-index CVT recurrence and/or VTE and mortality. Outcomes were pooled using random-effects meta-analysis. Prespecified subgroups included anticoagulation status, subtypes, and CVT recanalization at follow-up. Results: Fifty-four studies (N=9,985 patients after first CVT) met inclusion criteria. The pooled CVT recurrence rate was 2.87% ( P