Abstract DP334: Divergent Choroid Plexus Hemodynamics Predict Hippocampal Integrity: Insights into Cerebrovascular Aging

Introduction: Vascular aging influences both cerebrovascular reserve and neurodegeneration, yet the role of the choroid plexus (CHP)—a critical vascular interface for cerebrospinal fluid production, immune signaling, and waste clearance—remains poorly defined. The hippocampus, highly sensitive to perfusion and metabolic compromise, is a key structure affected in vascular cognitive impairment. We examined how distinct CHP hemodynamic parameters relate to hippocampal integrity in older adults. Objective: To interrogate the associations between CHP perfusion, total blood flow, and volume with hippocampal volume in community dwelling older adults. Methods: We studied 278 community dwelling healthy adults (52–83 years; 130 men, 148 women) using arterial spin labeling MRI to quantify CHP perfusion and structural MRI for CHP and hippocampal volumetrics. Multiple linear regression models tested independent associations of CHP perfusion, CHP blood flow, and CHP volume with hippocampal volume, controlling for age, sex, and intracranial volume. Results: The model explained 24.3% of variance in hippocampal volume (R-square=0.243, p