Abstract TP136: Trends in Mortality due to Stroke among Adult Smokers in the US from 2005-2023: Insights from CDC WONDER

Introduction: Smoking is a preventable risk factor for stroke. Compared to non smokers, current smokers have a 1.7 to 1.9 times higher risk of stroke and stroke related death, due to mechanisms like accelerated atherosclerosis, hypercoagulability, vascular inflammation, and impaired cerebral perfusion. In the United States, nearly one in five adults (approximately 49.2 million people) smoke cigarettes. Smoking even one cigarette per day is associated with a 25% to 30% increased stroke risk. This study analyzed mortality trends associated with stroke among smokers to understand the burden of stroke-related deaths and guide preventive strategies. Methods: We analyzed mortality due to stroke (ICD-10 code: I60-I69) in patients addicted to nicotine smoke (ICD-10 code: F17) using publicly available death certificates from the CDC-WONDER database from 2005 to 2023. Age-Adjusted Mortality Rates (AAMR) per 100,000 were calculated and categorized by demographics and region. Joinpoint regression was used to estimate Annual Percent Change (APC) and Average Annual Percent Change (AAPC) in AAMR. Results: A total of 148,911 deaths were attributed to stroke among adult smokers between 2005 and 2023. The AAMR first increased from 2.28 in 2005 to 3.89 in 2019 (APC: 4.05; 95% CI: 3.76 to 4.34; p