Abstract TP185: Application of TOAST Criteria, Comorbidities and Outcomes in Patients with Ischemic Stroke: Multicenter Collaboration in the Dominican Republic

Introduction: Stroke is the leading cause of neurological -related deaths in the Caribbean. The Dominican Republic amongst the highest stroke-related mortality rates in The Americas.We aim is to determine stroke etiologies, define common comorbidities and outcomes for stroke in the Dominican Republic utilizing TOAST (The Trial of Org 10172 in Acute Stroke Treatment) etiological classification. Methods: Multicenter retrospective study of ischemic stroke patients between January 2022 and October 2024 using the Registry of Stroke Care Quality (RES-Q). Statistical analyses included t-tests/ANOVA, Chi-square, logistic regression, and correlation. Results: Of 976 patients, 57% were male. Most strokes were undetermined etiology (54.8%), followed by large artery atherosclerosis (17.2%) and cardioembolism (16.5%). Cardioembolic strokes had the highest mean NIHSS (9), followed by large artery atherosclerosis and other determined etiologies (7). Stroke severity correlated with older age, HIV, atrial fibrillation/flutter, prior stroke, and heart failure (p