Abstract WP111: Fibromuscular Dysplasia and Cerebrovascular Dissection: Insights from a Multicenter Cohort

Background and aims: Fibromuscular dysplasia (FMD) is a systemic non-inflammatory arteriopathy that can cause arterial stenosis, dissections, aneurysms, and vessel tortuosity. Data remains limited on outcomes among FMD patients with spontaneous cervical arterial dissection (SCeAD). This study aimed to characterize clinical features and outcomes in this population. Methods: We conducted a retrospective multicenter cohort study of patients diagnosed with cervical carotid and/or vertebral artery dissection and FMD at three Southeast U.S. comprehensive stroke centers (2018-2023). Patients were identified via hospital records and vascular registries. Diagnoses were confirmed through imaging and reviewed by vascular neurologists or cardiologists. Outcomes included recurrent dissections, cardiovascular events (ischemic stroke, transient ischemic attack, myocardial infarction, subarachnoid hemorrhage) and mortality. Results: Among 1,632 patients with SCeAD, 97(6%) had FMD diagnosis. The cohort was predominantly female (91%) and median age at FMD diagnosis is 50 years(IQR 42-63). Carotid dissections were more frequent than vertebral dissections (86%vs.27%, p