Abstract WP113: Stroke in the Young: Sex Differences in Risk Factors, Etiologies, Acute Treatments, and Outcomes in a Nationwide Analysis

Introduction: Stroke in the young (SITY), defined as acute ischemic stroke (AIS) in patients aged 18–50, is a growing public health concern with unique etiologic and clinical features. Sex differences in vascular risk profiles, stroke etiologies, treatments, and outcomes in SITY remain poorly understood. Methods: Using the 2022 National Inpatient Sample, we identified all adult AIS patients aged 18-50 using ICD codes and stratified them by sex. Risk factors, acute treatments, stroke etiologies, and outcomes were compared between sexes using survey-weighted analysis. Results: Of the 64,110 SITY hospitalizations, 54.0% were male. Females had lower rates of hypertension (61.3 vs 67.7%) and hyperlipidemia (36.5 vs 40.7%), but higher rates of obesity (30.3 vs 24.4%) ( all p