Abstract WP154: Exploring the Obesity Paradox: Associations of BMI, WHR, and Their Combination with Stroke Recurrence and All-Cause Mortality in the UK Biobank

Background: Obesity is a known risk factor for cardiovascular disease and stroke. However, many studies have shown that higher body weight may be associated with lower mortality in patients with established disease. Body mass index (BMI) is widely used but cannot distinguish fat distribution, while waist-to-hip ratio (WHR) better reflects central obesity. This study examined the independent and combined effects of BMI and WHR on stroke recurrence and all-cause mortality. Methods: We included 2366 UK Biobank participants with a history of only one previous stroke. Baseline demographics, clinical factors, and lifestyle variables were collected. Missing data were handled by multiple imputation. Cox proportional hazards models assessed the associations of BMI(≥25 vs