Abstract WP211: Association of Infection with 3- and 6-Month Outcomes after Intracerebral Hemorrhage

Introduction: Infections, including urinary tract infections (UTI) and pneumonia, affect up to a fourth of patients after an intracerebral hemorrhage (ICH), negatively impacting 3-month functional outcomes independent of hemorrhage severity. However, associations beyond the 3-month period have not been studied. We have leveraged a multi-site, prospective, observational study that enrolled spontaneous ICH patients with 3- and 6-month outcomes to investigate this association. Methods: We identified acute ICH cases from 6 sites across the US between 2017-2024 with and without infection (pneumonia and UTI). Univariate analysis was performed to evaluate the individual association of certain variables (race, sex, comorbidities, and ICH characteristics) with 3- and 6-month outcomes. Multivariate logistic regression analysis using backward elimination methodology was conducted to determine the independent association of variables, including infection, on the 3- and 6-months outcomes. Our primary outcome was dichotomized modified Rankin Scale (mRS) with mRS 0-3 representing good and mRS 4-6 representing poor outcome. Variables with a p