Abstract WP336: Trends, Predictors and Inpatient Outcomes in Takotsubo Cardiomyopathy and Stroke: An Analysis of the National Inpatient Sample Data

Background: Several case series and small observational studies have highlighted that Takotsubo Cardiomyopathy (TTC) might be a risk factor for Ischemic Stroke. This study aims to study the prevalence and incidence of stroke in TTC patients using the National Inpatient Sample Data. Methodology: We analysed the National Inpatient Sample data for the years 2016-2022 using STATA. The ICD-10 code I63 for stroke and I51. 81 for TTC were utilised. The prevalence was determined overall and yearly using descriptive statistics and employing the measures of central and peripheral tendencies. A survey-weighted regression analysis was performed to determine the independent factors associated with TTC. Furthermore, we used the Elixhauser comorbidity index for comorbidities. The p-value was kept significant at ≤ 0.05 with a 95% Confidence interval (CI). Results: Among stroke admissions (6,046,398), TTC was uncommon but present [0.279%, 95% CI: 0.268–0.290] and rose from 0.240% (2016) to 0.324% (2021–2022). Among TTC admissions, 5.78% (95% CI: 5.57–6.00) had a stroke, increasing from 4.99% in 2016 to 6.51% in 2021. Within the stroke cohort, TTC cases were more often female (74.7% vs 48.5%) and had worse outcomes: higher in-hospital mortality (21.7% vs 9.5%), longer length of stay (13.68 vs 7.36 days), and higher cost ($246,511 vs $111,325). Concomitant stroke was associated with higher odds of death [OR = 3.41, (95% CI: 3.08–3.78), p