Abstract WP379: Biomarkers of neuroplasticity in predicting outcomes of hemorrhagic strokes

Background: Glial cell line–derived neurotrophic factor (GDNF), predominantly expressed by astrocytes, plays an important role in regulating microglial activation during hemorrhagic stroke. By modulating neuroinflammation, GDNF may protect against neurodegeneration and contribute to recovery through neuroplasticity. Aim: To evaluate the role of GDNF in the acute phase of hemorrhagic stroke and its potential as a biomarker for predicting clinical outcomes. Methods: A total of 83 patients with acute hemorrhagic stroke of various localizations were examined. Of these, 45 (54.2%) were men and 38 (45.7%) women, with a mean age of 62.3 years. All patients underwent standardized clinical and neurological assessment. Stroke severity and functional status were evaluated using the NIHSS, FOUR, Barthel Index, and Rankin scale, allowing classification into groups by disease severity. Results: In the control group, the mean GDNF level was 28.1 pg/ml. In patients with hemorrhagic stroke, GDNF levels measured within the first 3 hours were significantly elevated at 46.7 pg/ml (p