Genetic Susceptibility to Adult Cerebral Venous Thrombosis: An Updated Meta-Analysis of Candidate Gene Studies
Abstract
BACKGROUND: Genetic predisposition is increasingly recognized as an important contributor to cerebral venous thrombosis (CVT), yet findings from individual studies remain inconsistent. We conducted an updated meta-analysis to quantify associations between specific genetic variants and adult CVT. METHODS: We systematically searched PubMed, EMBASE, and Web of Science up to January 2025 for case-control studies comparing the prevalence of genetic variants in adults with CVT versus healthy controls. Pooled odds ratios (ORs) with 95% CIs were calculated using random-effects models in this meta-analysis. RESULTS: Sixty-one studies comprising 4106 patients with CVT and 12 323 controls were analyzed. Significant associations were identified for germline variants, including factor V Leiden (238/2753 [8.6%] versus 387/8747 [4.4%]; OR, 2.59 [95% CI, 2.06–3.26]; P
Fields of Study & Subjects
Cerebral Venous Sinus Thrombosis
Blood Coagulation and Thrombosis Mechanisms
Hearing
Cochlea
Tinnitus
Genetics
Publication details
- Journal / source
- Stroke
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 57
- Issue
- 3
- Pages
- 684–696
- Publication date
- 2 January 2026
- Language
- EN