Patterns and Factors Associated With Cerebral Infarction on MRI in Tuberculous Meningitis: Secondary Analysis of the ACT-TBM Trial.

PubMed 2026

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Authors: Meena Chandu, Rohit Bhatia, Manish Modi, Ritu Shree, Imnameren Longkumer, Ajay Garg, Nalin Sharma, Sameer Vyas, Chirag K Ahuja, Mamta Bhushan Singh, Kusum Sharma
DOI: 10.1161/strokeaha.125.054034
Cited by: 1

Abstract

BACKGROUND: Cerebral infarction is a frequent and serious complication of tuberculous meningitis (TBM), contributing substantially to morbidity and mortality. Moreover, studies on infarct patterns and associated factors/predictors remain limited in TBM. ACT-TBM trial (Aspirin or Clopidogrel Therapy in the Treatment of Tuberculous Meningitis) evaluated the efficacy and safety of adjunctive antiplatelet therapy (aspirin or clopidogrel) to standard antitubercular therapy in TBM for the occurrence of stroke or cerebral infarction. Here, we conducted a secondary analysis of the ACT-TBM trial to characterize the patterns, associated factors, and predictors of cerebral infarction in TBM. METHODS:

Fields of Study & Subjects

Infectious Diseases and Tuberculosis Tuberculosis Research and Epidemiology Sarcoidosis and Beryllium Toxicity Research

Publication details

Journal / source
PubMed
Volume
57
Issue
4
Pages
856–864
Publication date
1 April 2026
Language
EN