Adjusting Antiplatelet Therapy Using P2Y 12 Reaction Units in Endovascular Treatment of Unruptured Intracranial Aneurysms

Stroke Vascular and Interventional Neurology 2026 Open access

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Authors: Eunji Moon, Yunsun Song, Jung Cheol Park, Boseong Kwon, Wonhyoung Park, Jae Sung Ahn, Deok Hee Lee, Dae Chul Suh
DOI: 10.1161/svin.124.001691
Cited by: 2
References: 30

Abstract

BACKGROUND: The effectiveness of platelet reactivity unit (PRU)–guided individualized antiplatelet therapy for intracranial aneurysm treatment remains uncertain. METHODS: This retrospective study evaluated 1705 patients with 1883 unruptured intracranial aneurysms who received endovascular treatments at a tertiary center between March 2018 and December 2020. Patients were divided into 2 groups: a standard group (aspirin and clopidogrel without PRU) and an individualized group where antiplatelet therapy was adjusted or switched to low-dose prasugrel based on preprocedural PRU values by VerifyNow. In the individualized group, hyporesponsiveness was defined as PRU>238 or inhibition

Fields of Study & Subjects

Intracranial Aneurysms: Treatment and Complications Antiplatelet Therapy and Cardiovascular Diseases Intracerebral and Subarachnoid Hemorrhage Research

Publication details

Journal / source
Stroke Vascular and Interventional Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
6
Issue
2
Pages
e001691–e001691
Publication date
21 January 2026
Language
EN