Visual Field Progression Rate and Laminar Depth and Curvature in the African Descent and Glaucoma Evaluation Study (ADAGES)

Abstract P urpose To determine if lamina cribrosa (LC) depth and curvature predict visual field (VF) progression rate in the African Descent and Glaucoma Evaluation Study (ADAGES) cohort in patients with primary open angle glaucoma (POAG). S ubjects Participants, and/or Controls. Three eyes from three research-consented brain-dead organ donors. M ethods Anterior laminar cribrosa surface depth (ALCSD) and LC curvature index (LCCI) were defined from 24 radial B-scan spectral domain optic coherence tomographic (SDOCT) images of each image. All scans were processed using a deep learning software to perform the segmentation and optic nerve health (ONH) layers. Univariable and multivariable linear mixed effects models were used to test associations between VF progression rate, ALCSD, and other demographic and clinical characteristics and known risk factors for progressive POAG. Additionally, the variable selection in the final multivariable model was reached using the Akaike information criterion index (AICc) and clinical utility. M easures IOP change with exposure to NP. M ain O utcome The associations between ALCSD and LCCI with the rate of VF progression. R esults There was a statistically significant relationship between faster VF progression rates, and a deeper ALCSD (−0.02 dB/year/50 microns, p