In morphea, cytotoxic resident memory T cells induce chronic, immunogenic endothelial cell injury via necroptosis

JCI Insight 2026 Open access

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Authors: William J. Crisler, Noor Sohail, Samuel J. Steuart, Maria Vazquez-Machado, Arjun Mahajan, Maureen Whittelsey, Alex Pickering, Michael J. Martinez, Theresa Hutchins, Jessica E. Teague, Qian Zhan, Shannan Ho Sui
+5 more Ruth Ann Vleugels, Kathryn S. Torok, Heidi T. Jacobe, Rachael A. Clark, Avery LaChance
DOI: 10.1172/jci.insight.201949
Cited by: 1
References: 6

Abstract

Chronic skin fibrosis in morphea results from resident memory T cells that kill endothelial cells through inflammatory cell death and sustain injury and scarring.

Fields of Study & Subjects

Cell death mechanisms and regulation Phagocytosis and Immune Regulation T-cell and B-cell Immunology

Publication details

Journal / source
JCI Insight
Publisher
American Society for Clinical Investigation
Volume
11
Issue
10
Publication date
2 April 2026
Language
EN