Cycling GLP-1 receptor agonist treatment induces therapeutic resistance and increased adiposity

JCI Insight 2026 Open access

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Authors: Anna J. Son, Emmanuel Rapp, Alex Wiezorek, Max Leung, Ronadip R. Banerjee, Thomas Leung
DOI: 10.1172/jci.insight.205174
Cited by: 1
References: 6

Abstract

Stopping and restarting GLP-1 weight-loss drugs in mice made them less effective over time and increased fat gain compared with continuous treatment.

Fields of Study & Subjects

Diabetes Treatment and Management Metabolism Diabetes and Cancer Pharmacology and Obesity Treatment

Publication details

Journal / source
JCI Insight
Publisher
American Society for Clinical Investigation
Volume
11
Issue
10
Publication date
31 March 2026
Language
EN