SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2

Journal of Clinical Investigation 2026 Open access

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Authors: Abdualrahman Mohammed Abdualkader, Xiaobei Li, Yiming Yin, Chenhao Bai, Parisa Pourfarziani, Jiaheng Guan, Sora Kwon, Kyoung-Han Kim, RAMI AL BATRAN
DOI: 10.1172/jci192333
Cited by: 1
References: 4

Abstract

SGLT2 inhibitors boost ketone production by directly activating a liver enzyme, revealing a new mechanism that may contribute to their heart and kidney benefits.

Fields of Study & Subjects

Diet and metabolism studies Diabetes Treatment and Management Peroxisome Proliferator-Activated Receptors

Publication details

Journal / source
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Volume
136
Issue
13
Publication date
30 June 2026
Language
EN