Elevated tRNA halves in olfactory epithelial cells of patients with schizophrenia

Journal of Clinical Investigation 2026 Open access

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Authors: Justin Gumas, Megumi Shigematsu, Karin E. Borgmann‐Winter, Chang-Gyu Hahn, Yohei Kirino
DOI: 10.1172/jci195148
Cited by: 0
References: 6

Abstract

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

Fields of Study & Subjects

RNA modifications and cancer RNA and protein synthesis mechanisms Schizophrenia research and treatment

Publication details

Journal / source
Journal of Clinical Investigation
Volume
136
Issue
2
Publication date
15 January 2026
Language
EN