Germline inactivation of tumor suppressor BAP1 is associated with white spotting

Journal of Clinical Investigation 2026 Open access

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Authors: Ching-Ni Jenny Njauw, Zhenyu Ji, David I. Latoni, José María Villa-González, Shelley R. McCormick, Raj Kumar, Dmitrii Usoltsev, Mykyta Artomov, Boyi Gan, Hensin Tsao
DOI: 10.1172/jci195809
Cited by: 0

Abstract

Inherited BAP1 mutations cause melanoma and other cancers and can also lead to white hair patches or skin spots due to pigment cell loss.

Fields of Study & Subjects

Melanoma and MAPK Pathways melanin and skin pigmentation Cutaneous Melanoma Detection and Management

Publication details

Journal / source
Journal of Clinical Investigation
Volume
136
Issue
1
Publication date
1 January 2026
Language
EN