Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases

Journal of Clinical Investigation 2026 Open access

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Authors: Bingyu Yan, Jinwoo Lee, Suhas Srinivasan, Torres Ambriz P, Quanming Shi, Diana R. Dou, Srijana Davuluri, Swarna Nandyala, Adrianne Woods, Gwendolyn Leatherman, Yanding Zhao, Roman E. Reggiardo
+6 more Manasi Sawant, Hawa Racine Thiam, Ami A. Shah, David F. Fiorentino, Lorinda Chung, Howard Y. Chang
DOI: 10.1172/jci198291
Cited by: 1
References: 5

Abstract

Novel autoantibodies target hotspots on the XIST ribonucleoprotein complex in female-biased autoimmune diseases.

Fields of Study & Subjects

Systemic Lupus Erythematosus Research Diabetes and associated disorders Complement system in diseases

Publication details

Journal / source
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Volume
136
Issue
7
Publication date
10 February 2026
Language
EN