Sinus mast cell accumulation and persistence suggest a unique endotype in toxin exposure–associated chronic rhinosinusitis

Journal of Clinical Investigation 2026 Open access

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Authors: Xinyu Wang, Yung-An Huang, Anshika Sethi, Christopher Yue, Sydney Brack, Aiswarya Chattuparambil Binoy, Lauren Crowther, Carol Hiu-Mei Yan, Adam DeConde, Anton Kushnaryov, Andrew M. Vahabzadeh-Hagh, Jacob Husseman
+6 more Maia Little, Allyssa Strohm, Lily Jih, Jonathan J. Lyons, David H. Broide, Taylor A. Doherty
DOI: 10.1172/jci201075
Cited by: 2
References: 6

Abstract

This study identifies a toxin-associated chronic rhinosinusitis endotype, defined by persistent mast cell accumulation, advancing understanding of how environmental exposures may drive chronic airway disease.

Fields of Study & Subjects

Sinusitis and nasal conditions Mast cells and histamine Allergic Rhinitis and Sensitization

Publication details

Journal / source
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Volume
136
Issue
8
Publication date
10 February 2026
Language
EN