Prognostic Significance of Multiple High-Risk Features in Stage II Colon Adenocarcinomas Compared With Stage III Disease

The American Surgeon 2026

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Authors: Ergin Erginöz, Muratcan Firat, Kevser Sak, Sefa Ergün, Kağan Zengin, Şebnem Batur, Nuray Kepil, Sinan Çarkman
DOI: 10.1177/00031348261425179
Cited by: 0
References: 23

Abstract

Introduction The prognostic significance of high-risk features (HRFs) in stage II colon cancer is established, but the cumulative impact of multiple HRFs and their relation to stage III disease remain unclear. This study evaluated whether patients with stage II colon adenocarcinomas with ≥3 HRFs demonstrate survival outcomes comparable to stage III disease. Methods A retrospective analysis included 377 patients who underwent curative resection for colon adenocarcinoma between 2016 and 2022. Patients were classified as stage II

Fields of Study & Subjects

Colorectal Cancer Surgical Treatments Colorectal Cancer Treatments and Studies Genetic factors in colorectal cancer

Publication details

Journal / source
The American Surgeon
Volume
92
Issue
7
Pages
1938–1947
Publication date
10 February 2026
Language
EN