Reference intervals for kidney tubular secretion markers in the general population: The HUNT3 study

Annals of Clinical Biochemistry International Journal of Laboratory Medicine 2026

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Authors: Marius Altern Øvrehus, Kåre A. Kristiansen, Knut Asbjørn Rise Langlo, Pranav S. Garimella, Joachim H. Ix, Michael G. Shlipak, Per Bruheim, Stein Ivar Hallan
DOI: 10.1177/00045632261454284
Cited by: 1
References: 40

Abstract

Background Chronic kidney disease (CKD) prevalence and prognosis are currently based exclusively on glomerular functions, but the kidney tubule possesses numerous additional functions with pathophysiological and prognostic value. Tubular secretion is also critical for toxin and drug elimination but has not been well described in healthy individuals and corresponding reference ranges have not been established. Material and methods Among participants from the Norwegian population-based HUNT3 study we identified a healthy subset by excluding those reporting poor general health, or smoking, diabetes, cardiovascular disease, treated hypertension, severe, and CKD (eGFR

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Urinary Tract Infections Management Urinary Bladder and Prostate Research

Publication details

Journal / source
Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Publisher
SAGE Publications
Pages
45632261454284–45632261454284
Publication date
12 May 2026
Language
EN