Expression and prognostic importance of lymphocyte activation gene 3 and CD73 in advanced or metastatic hepatocellular carcinoma

Journal of International Medical Research 2026 Open access

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Authors: Murat Ayhan, Akif Dogan, Sevinç Hallaç Keser, Kayhan Başak, Nadiye Akdeniz, Muhammed Mustafa Atçı, Selma Şengiz Erhan, Rukiye ARIKAN, Çiğdem Çelikel, Nedim Turan, Mahmut Emre Yıldırım, Hatice Odabaş
+3 more Sedat Yıldırım, Şahin Laçin, Osman Köstek
DOI: 10.1177/03000605251386599
Cited by: 0
References: 49

Abstract

Objective In this study, we aimed to investigate the prognostic significance of the expression of lymphocyte activation gene 3 and CD73 in advanced or metastatic hepatocellular carcinoma as well as its predictive effect on disease control rates in patients receiving sorafenib. Methods Data from 79 patients diagnosed with hepatocellular carcinoma in 3 different oncology centers between 2012 and 2021 were analyzed. Of these patients, 67 were included in this study based on the inclusion and exclusion criteria. The correlation between the expression of lymphocyte activation gene 3 and CD73 and clinical features was analyzed. Results Of the 67 patients included in the study, 80.6% were males, and the median age at diagnosis was 65 (55–73) years. A baseline alpha-fetoprotein level of

Fields of Study & Subjects

Hepatocellular Carcinoma Treatment and Prognosis Colorectal Cancer Treatments and Studies Head and Neck Cancer Studies

Publication details

Journal / source
Journal of International Medical Research
Volume
54
Issue
1
Pages
3000605251386599–3000605251386599
Publication date
1 January 2026
Language
EN