Application of the CA330 cytokine adsorption cartridge for coupled plasma filtration adsorption therapy in severe acute pancreatitis-induced cytokine storm: A case report

This case describes an 82-year-old male patient presenting with persistent upper abdominal colic, diagnosed as severe acute pancreatitis. The patient then suffered a cytokine storm, as well as renal dysfunction. Therefore, the patient underwent two sessions of coupled plasma filtration adsorption (CPFA) therapy utilising the CA330 cytokine adsorption cartridge as the adsorbent. The first CPFA session lasted 8 h, followed by a 4-h interval (during which continuous veno-venous haemodialysis therapy was provided), and the second 8-h CPFA session started. Due to family requests and comprehensive consideration by the medical team, the second CPFA session was extended to 20 h. Ultimately, the patient was weaned off blood purification therapy (43 h after its initiation). The study demonstrated a significant reduction in cytokine levels as the course of treatment increased. However, beyond a specific threshold, cytokine adsorption may reach saturation. The medicinal applications of CPFA (particularly CA330) deserve more investigation.