Management of a Kratom and Tianeptine Overdose
Abstract
A middle-aged man with a history of polysubstance abuse presented with acute hypoxemic respiratory failure following self-reported ingestion of kratom and tianeptine. Initial evaluation showed significant respiratory depression, hypoxia, bilateral pulmonary infiltrates, and acute encephalopathy. Symptomatic management, naloxone administration, and ICU-level supportive care led to gradual clinical improvement. This case highlights the potential for severe respiratory and neurological compromise with combined kratom and tianeptine toxicity.
Fields of Study & Subjects
Alkaloids: synthesis and pharmacology
Plant-based Medicinal Research
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- Journal of Pharmacy Practice
- Publisher
- SAGE Publications
- Pages
- 8971900261456021–8971900261456021
- Publication date
- 26 May 2026
- Language
- EN