Pre-Radioiodine Thyrotropin Thresholds During Withdrawal Preparation in Differentiated Thyroid Cancer after Total Thyroidectomy: A Systematic Review and Meta-Analysis

Thyroid 2026

View at publisher
Authors: Tatiana Rojas, Paola Solís-Pazmiño, Luis Figueroa, Tannya M. Ledesma, Eduardo Pilatuña, Camila N. Pazmino-Chavez, Eddy P. Lincango Naranjo, María Belén Tite-Haro, Benjamin Alvarado-Mafla, Francisco J. Barrera-Flores, Yosef Nasseri, Jason Cohen
+3 more David Toro-Tobon, Oscar J. Ponce, Juan Pablo Brito
DOI: 10.1177/10507256261423206
Cited by: 1
References: 24

Abstract

BACKGROUND: Preparation for radioiodine (RAI) therapy in differentiated thyroid cancer (DTC) often requires thyroid hormone withdrawal (THW) to achieve thyrotropin (TSH) stimulation. Current guidelines recommend TSH ≥30 mIU/L, a target that prolongs hypothyroidism and worsens quality of life, yet rests on limited evidence. OBJECTIVE: To evaluate the association between pre-RAI TSH levels and oncologic outcomes in adults with DTC prepared by THW. METHODS: We conducted a systematic review and meta-analysis of studies comparing outcomes across pre-RAI TSH thresholds (

Fields of Study & Subjects

Thyroid Cancer Diagnosis and Treatment Thyroid Disorders and Treatments Radiopharmaceutical Chemistry and Applications

Publication details

Journal / source
Thyroid
Publisher
SAGE Publications
Volume
36
Issue
3
Pages
229–241
Publication date
11 February 2026
Language
EN