Radiotherapy Response Prediction in Myxofibrosarcomas and Undifferentiated Soft Tissue Sarcomas Using DNA Methylation and Copy Number Profiling

International Journal of Surgical Pathology 2026 Open access

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Authors: Tony G. Kleijn, Baptiste Ameline, Wierd Kooistra, Léon C.L.T. van Kempen, Gilles F.H. Diercks, Robert J. van Ginkel, Lukas B. Been, Barbara L. van Leeuwen, Anna K.L. Reyners, Thomas Christian Kwee, Paul C. Jutte, Joris J. W. Ploegmakers
+8 more Henk P. Bijl, Bart Vanhauten, Jan F. Ubbels, Ed M. D. Schuuring, Albert J.H. Suurmeijer, Jacco Juri de Haan, Daniel Baumhoer, Arjen H.G. Cleven
DOI: 10.1177/10668969251412902
Cited by: 0
References: 24

Abstract

BackgroundMyxofibrosarcoma (MFS) and undifferentiated soft tissue sarcoma (USTS) are common sarcoma subtypes with overlapping molecular features. Both are treated with neoadjuvant radiotherapy followed by surgery, yet radiotherapy response is variable and unpredictable. This study investigated DNA methylation and copy number variation (CNV) profiles obtained from pre-radiotherapy biopsies as predictive biomarkers of radiotherapy response.Patients and methodsPre-radiotherapy biopsies and post-radiotherapy resections were obtained from 49 patients (27 MFS, 22 USTS). Radiotherapy response was assessed on the resection specimens using the EORTC-STBSG 5-tier system; grades A-C (

Fields of Study & Subjects

Sarcoma Diagnosis and Treatment Chromatin Remodeling and Cancer Bone Tumor Diagnosis and Treatments

Publication details

Journal / source
International Journal of Surgical Pathology
Volume
34
Issue
4
Pages
920–928
Publication date
29 January 2026
Language
EN