Risk Stratification for Underlying Cervical Intraepithelial Neoplasia Grade (CIN)3+ in Reproductive-Age Women With Biopsy-Confirmed CIN2: Implications for Fertility-Preserving Management

Cancer Control 2026 Open access

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Authors: Hangjing Gao, Qiao Gao, Lifang Xue, Hao Lin, Diling Pan, Xiqi Huang, Huifeng Xue, Z.J. Wang, XiaoQi Sun
DOI: 10.1177/10732748261427836
Cited by: 1
References: 34

Abstract

Introduction Managing biopsy-confirmed cervical intraepithelial neoplasia grade 2 (CIN2) in women of reproductive age poses clinical challenges. Immediate treatment with large-loop excision of the transformation zone (LLETZ) is associated with a substantial risk of adverse obstetric outcomes. This study aimed to identify the risk factors for predicting CIN3+ lesions in reproductive-aged women with biopsy-diagnosed CIN2, to inform personalized management strategies that are particularly relevant to China’s evolving fertility policies. Methods This retrospective cohort study analyzed the data from a regional cervical lesion screening database. Reproductive-aged women (

Fields of Study & Subjects

Cervical Cancer and HPV Research Endometrial and Cervical Cancer Treatments Reproductive tract infections research

Publication details

Journal / source
Cancer Control
Publisher
SAGE Publications
Volume
33
Pages
10732748261427836–10732748261427836
Publication date
19 February 2026
Language
EN