Immediate Brainstem Hemorrhage after Thrombolysis in Ischemic Stroke With Poorly Controlled Hypertension: Insights From Three Clinical Cases

Journal of Central Nervous System Disease 2026 Open access

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Authors: Lei Shen, Niao Yang, Dong Sun, Bin Mei, Nao Yan
DOI: 10.1177/11795735251409050
Cited by: 1
References: 26

Abstract

Objective: To report three cases of immediate brainstem hemorrhage following intravenous thrombolysis with tenecteplase (TNK) in patients with minor ischemic stroke, resulting in poor outcomes and death. Methods: We describe the clinical characteristics, imaging findings, and outcomes of three patients who developed brainstem parenchymal hemorrhage immediately after TNK thrombolysis. Results: All three patients had minor ischemic stroke (National Institute of Health stroke scale score ≤5) and presented with elevated blood pressure on admission. Blood pressure was lowered to guideline-recommended levels (

Fields of Study & Subjects

Acute Ischemic Stroke Management Intracerebral and Subarachnoid Hemorrhage Research Traumatic Brain Injury and Neurovascular Disturbances

Publication details

Journal / source
Journal of Central Nervous System Disease
Publisher
SAGE Publications
Volume
18
Pages
11795735251409050–11795735251409050
Publication date
2 January 2026
Language
EN