Clinical and MRI substrates of Symbol Digit Modalities Test impairment in multiple sclerosis patients with an adult- and late-onset

Multiple Sclerosis Journal 2026 Open access

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Authors: Antonia Wenger, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Antonio Gallo, Elisabeth Solana, Menno Michiel Schoonheim, Christian Enzinger, Sergiu Groppa, Mario Ocampo‐Pineda, Alessandro Cagol, Matthias Weigel
+5 more Pasquale Calabrese, Ludwig Kappos, Cristina Granziera, Massimo Filippi, Maria Assunta Rocca
DOI: 10.1177/13524585261417265
Cited by: 0
References: 32

Abstract

Background: Multiple sclerosis (MS) onset occurs at diverse ages. Age of onset impact on clinical, brain MRI, and cognitive profiles remains unclear. We investigated the substrates of Symbol Digit Modalities Test (SDMT) impairment in patients with late-onset MS (LOMS) (⩾45 years) compared to adult-onset MS (AOMS) (

Fields of Study & Subjects

Multiple Sclerosis Research Studies Functional Brain Connectivity Studies Advanced Neuroimaging Techniques and Applications

Publication details

Journal / source
Multiple Sclerosis Journal
Volume
32
Issue
3
Pages
289–301
Publication date
23 February 2026
Language
EN