Comparative effects of TDP-43-A and TDP-43-α on hippocampal subfields and amygdala nuclei

Journal of Alzheimer s Disease 2026 Open access

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Authors: Hossam Youssef, Rodolfo G. Gatto, Nikhil B Ghayal, Ronald Carl Petersen, Clifford R. Jack, R. Ross Reichard, Dennis W. Dickson, Jennifer Louise Whitwell, Keith A. Josephs
DOI: 10.1177/13872877261426494
Cited by: 0
References: 44

Abstract

Transactive response DNA-binding protein of 43 kDa (TDP-43) type-A is associated with frontotemporal lobar degeneration (FTLD). In primary age-related tauopathy (PART), TDP-type-α displays similar features to FTLD-TDP type-A. We compared antemortem MRI volumes of amygdala nuclei and hippocampal subfields between 16 PART-TDP-α and 12 FTLD-TDP-A autopsy-confirmed cases. Hippocampal tail and CA1 body volumes were smaller in PART-TDP-α group, which also had smaller lateral and central amygdala nuclei compared to FTLD-TDP-A group, but differences were non-significant after FDR correction. There is no evidence suggesting that TDP-43 type-A in FTLD affects hippocampal and amygdala volume loss differently than TDP-43 type-α in PART.

Fields of Study & Subjects

Amyotrophic Lateral Sclerosis Research Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments

Publication details

Journal / source
Journal of Alzheimer s Disease
Volume
110
Issue
4
Pages
1615–1622
Publication date
16 March 2026
Language
EN