Tet2 and Jak2 clonal hematopoiesis do not modify murine tauopathy

Journal of Alzheimer s Disease 2026

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Authors: Lena Gaebel, Teresa Gerhardt, Annie Khamhoung, Pacific Huynh, Merlin Heiser, Niki F. Brisnovali, Walter Jacob, Abi G. Yates, Aaron Douglas, Trevor Fidler, Leigh Goedeke, Cameron S. McAlpine
DOI: 10.1177/13872877261458734
Cited by: 1
References: 33

Abstract

Background Clonal hematopoiesis (CH) increases with age and elevates the risk of numerous age-associated diseases. However, the association between CH and neurodegenerative diseases has remained unclear. Objective We tested the association between the presence of CH and tauopathy in a murine model. Methods We established novel models of Tet2 loss-of-function and Jak2 gain-of-function (V617F) CH in CD45.1-expressing PS19 tauopathy mice using unconditioned bone marrow (BM) cell transfer, thereby maintaining brain integrity, clonal expansion, and enabling mutant cell tracking. Results In CD45.1- PS19 mice, Tet2 -/- cells (CD45.2) started at a fraction of

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Neurogenesis and neuroplasticity mechanisms Immune cells in cancer

Publication details

Journal / source
Journal of Alzheimer s Disease
Publisher
SAGE Publications
Volume
112
Issue
3
Pages
1415–1427
Publication date
18 June 2026
Language
EN