Necrotizing gingival infection due to Trichoderma longibrachiatum in an hematopoietic stem cell transplant recipient: case report

Therapeutic Advances in Infectious Disease 2026 Open access

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Authors: Eduardo Aparicio-Minguijón, Nieves Lopez-Munoz, Pilar Martínez-Sánchez, María Calbacho, Ana Pérez-Ayala, Justino Jiménez-Almonacid, María Asunción Pérez‐Jacoiste Asín, Isabel Rodríguez-Goncer
DOI: 10.1177/20499361251403060
Cited by: 1
References: 12

Abstract

Trichoderma is a genus of rare filamentous fungi that can cause invasive fungal infections in immunocompromised patients. We report a case of necrotizing gingival and sinus infection due to T. longibrachiatum in an allogeneic stem cell transplant recipient. The patient received a combination of antifungal and aggressive surgical debridement, achieving clinical cure. The treatment included amphotericin B, voriconazole and caspofungin with the latter switch to rezafungin to consolidate therapy. Rezafungin might represent a useful alternative for fungal infections with limited therapeutic options, but further studies are needed to confirm its role in Trichoderma spp. infections.

Fields of Study & Subjects

Antifungal resistance and susceptibility Oral microbiology and periodontitis research Fungal Infections and Studies

Publication details

Journal / source
Therapeutic Advances in Infectious Disease
Publisher
SAGE Publications
Volume
13
Pages
20499361251403060–20499361251403060
Publication date
1 January 2026
Language
EN