Atypical presentation of DRESS/DiHS mimicking an acquired ichthyosis: A case report of bortezomib-induced severe erythroderma in multiple myeloma
Abstract
We present a case of severe and atypical Drug Reaction with Eosinophilia and Systemic Symptoms/Drug-induced hypersensitivity Symptoms (DRESS/DiHS), also known as DiHS, in a 46-year-old Chinese woman, triggered by bortezomib (Velcade), a proteasome inhibitor, commonly used for the treatment of multiple myeloma. Bortezomib-induced DRESS/DiHS syndrome is rare, with this being the second case documented in the literature. The patient presented with severe erythroderma with ichthyosis-like features, hypereosinophilia, and liver injury. Initial response to high dose of solumedrol was followed by relapses upon switching to oral prednisone. Ultimately, the patient responded to dupilumab and maintained complete remission.
Fields of Study & Subjects
Drug-Induced Adverse Reactions
Multiple Myeloma Research and Treatments
Eosinophilic Disorders and Syndromes
Publication details
- Journal / source
- SAGE Open Medical Case Reports
- Publisher
- SAGE Publications
- Volume
- 14
- Pages
- 2050313X251411500–2050313X251411500
- Publication date
- 1 January 2026
- Language
- EN