Chilblain lupus: A rare form of cutaneous lupus erythematosus — A case report

SAGE Open Medical Case Reports 2026 Open access

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Authors: Gabriele Perazzolli, Elia Banchetti, Enrico Melis, Antonio Carletto, Giampiero Girolomoni, Paolo Gisondi
DOI: 10.1177/2050313x261415591
Cited by: 0
References: 12

Abstract

Chilblain lupus erythematosus is a rare, cold-induced form of chronic cutaneous lupus that can occur in both genetic and sporadic forms. It is characterized by acral skin lesions and is commonly associated with autoimmunity and type I interferon pathway activation. Diagnosis is based on clinical features and histological findings. While topical and systemic therapies can be effective, the disease is often chronic and relapsing. We describe a case of a 48-year-old woman with chilblain lupus erythematosus who achieved almost complete clinical remission following treatment with hydroxychloroquine and methotrexate.

Fields of Study & Subjects

Systemic Lupus Erythematosus Research Dermatological and COVID-19 studies Systemic Sclerosis and Related Diseases

Publication details

Journal / source
SAGE Open Medical Case Reports
Volume
14
Pages
2050313X261415591–2050313X261415591
Publication date
1 January 2026
Language
EN