Perceptions of Maternal Respiratory Syncytial Virus Recommendations in the United States

Background: Respiratory syncytial virus (RSV) is a leading cause of U.S. hospitalizations in infants. Current guidelines recommend vaccination during pregnancy or immunizing infants after birth to protect infants from RSV. While research has shown pregnant people are in favor of preventative measures for RSV, overall coverage remains relatively low. This study aimed to gather insight into RSV vaccine perceptions, preferred method of prevention, degree of health care providers (HCPs) recommendation, and timing for discussion and vaccination. Methods: A 10-minute online survey was administered to pregnant adults and new mothers in December 2024. Data on respondents’ preference for prevention, impact of the strength of HCP recommendation, and preferred timing and location for discussion were collected. Results: Among 800 respondents, 65% showed preference for vaccination during pregnancy over immunizing their baby post-birth. A strong HCP recommendation is associated with a higher maternal vaccination acceptance rate (56% “definitely” would vaccinate) compared with a lighter recommendation (47%). Preferred timing for this discussion is during an initial appointment (33%) or a few weeks before they would receive the vaccine (42%). About 84% of respondents prefer having the choice to vaccinate during pregnancy, even if their infants are born outside of the typical RSV season. Conclusions: The majority of respondents in our study believed that protecting their infants from RSV was important, and approximately two-thirds preferred vaccination during pregnancy. Higher vaccination uptake is achievable with a strong HCP recommendation, earlier HCP counseling during pregnancy, and flexible vaccination timing outside a typical RSV season.