Jagged2-Notch axis: keeping stem cells in asymmetric balance
Abstract
In this issue of Blood, Matteini et al 1 demonstrate that age-associated loss of Jagged2 (J2) expression by bone marrow endothelial cells (BMECs) impairs hematopoietic stem cell (HSC) polarity, asymmetric cell division (ACD), and regenerative potential by promoting cis inhibition of Notch signaling during aging.This study elegantly integrates decades of observations, proposing J2/Notch interaction as a key regulator of HSC divisional symmetry and aging and offering insights that may inform strategies to restore regenerative function in aged hematopoiesis.
Fields of Study & Subjects
Developmental Biology and Gene Regulation
Planarian Biology and Electrostimulation
Neurogenesis and neuroplasticity mechanisms
Publication details
- Journal / source
- Blood
- Volume
- 147
- Issue
- 2
- Pages
- 99–100
- Publication date
- 8 January 2026
- Language
- EN