Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia

Blood 2026

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Authors: Marco Becilli, Pietro Merli, Mattia Algeri, Francesca Del Bufalo, Daria Pagliara, Valentina Bertaina, Chiara Agrati, Chiara Rosignoli, Maria Giuseppina Cefalo, Emilia Boccieri, Stefano Di Cecca, Laura Iaffaldano
+6 more Yunqin Lee, Biagio De Angelis, Soheil Meshinchi, Concetta Quintarelli, Dario Campana, Franco Locatelli
DOI: 10.1182/blood.2025032299
Cited by: 5
References: 24

Abstract

ABSTRACT: Autologous second-generation CD7-directed chimeric antigen receptor T cells, expressing an anti-CD7 protein expression blocker to prevent self-killing fratricide, were infused in 3 pediatric/young adult patients with relapsed/refractory CD7+ acute myeloid leukemia, resulting in measurable residual disease negativity. The safety profile was favorable.

Fields of Study & Subjects

CAR-T cell therapy research Acute Lymphoblastic Leukemia research Immune Cell Function and Interaction

Publication details

Journal / source
Blood
Publisher
American Society of Hematology
Volume
147
Issue
24
Pages
2981–2985
Publication date
3 March 2026
Language
EN