Time of infusion does not significantly impact outcomes following CAR T-cell therapy in large B-cell lymphoma

Blood 2026

View at publisher
Authors: Mark R. Dowling, Edward R. Scheffer Cliff, Anthony Jeffrey, Catelyn Cashion, Stephen Boyle, Jian Li, Thomas Buss, R. MacDonald, Anastasia Edelkina, Hamish W Scott, Nicole O'Leary, Michelle Wendy Keir
+11 more Safia Belbachir, D. Westerman, Constantine S. Tam, P. Joy Ho, Simon J Harrison, Allison Barraclough, Shafqat Inam, Emily Blyth, Andrea Henden, Vinay Vanguru, Michael Dickinson
DOI: 10.1182/blood.2025032307
Cited by: 2
References: 17

Abstract

ABSTRACT: In this retrospective analysis of 584 patients who received chimeric antigen receptor T-cell therapy for large B-cell lymphoma at 6 Australian centers, no association was found between time of infusion and outcome, accounting for confounders, suggesting minimal clinical impact of chronobiology in this setting.

Fields of Study & Subjects

CAR-T cell therapy research Lymphoma Diagnosis and Treatment Chronic Lymphocytic Leukemia Research

Publication details

Journal / source
Blood
Publisher
American Society of Hematology
Volume
147
Issue
19
Pages
2272–2277
Publication date
17 February 2026
Language
EN