Platelet-derived TGF-β1 and Treg maintenance in a murine model of ITP
Abstract
ABSTRACT: Studies suggest that platelet-derived transforming growth factor (TGF)-β1 is critical to immune thrombocytopenia tolerance via regulatory T-cell (Treg) modulation, but their implausibly high TGF-β1 levels likely reflect ex vivo artifacts. We could not confirm platelet-derived TGF-β1-driven Treg deficiency using knockout mice; remission maintenance likely involves extra-platelet TGF-β1 sources.
Fields of Study & Subjects
Platelet Disorders and Treatments
Immunodeficiency and Autoimmune Disorders
TGF-β signaling in diseases
Publication details
- Journal / source
- Blood
- Publisher
- American Society of Hematology
- Volume
- 148
- Issue
- 2
- Pages
- 258–260
- Publication date
- 20 April 2026
- Language
- EN