Hematologic malignancies in pediatric patients with RUNX1 -familial platelet disorder with associated myeloid malignancy

Blood Advances 2026 Open access

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Authors: Amra Kajdic, Natalie Deuitch, Erica Bresciani, Shawn Chong, Kathleen Marie Craft, Michelly Sampaio De Melo, Joie Davis, Roa Bashtawi, Nisha Patel, Lisa J. McReynolds, Neelam Giri, Katherine R. Calvo
+2 more David J. Young, Paul Liu
DOI: 10.1182/bloodadvances.2025017808
Cited by: 3
References: 45

Abstract

ABSTRACT: Deleterious germ line RUNX1 variants cause familial platelet disorder with associated myeloid malignancy (FPDMM), characterized by thrombocytopenia, platelet dysfunction, and predisposition to hematologic malignancies (HM). We examined clinical and laboratory findings of pediatric (

Fields of Study & Subjects

Acute Myeloid Leukemia Research Eosinophilic Disorders and Syndromes Blood disorders and treatments

Publication details

Journal / source
Blood Advances
Publisher
American Society of Hematology
Volume
10
Issue
9
Pages
3075–3085
Publication date
30 January 2026
Language
EN