Low flow cytometry events in detecting CNS involvement in pediatric B-cell precursor ALL: NGS validation and prognostic significance

Blood Advances 2026 Open access

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Authors: Shu-Wei Chou, Ying-Hui Su, Meng-Yao Lu, Hsiu-Hao Chang, Yung‐Li Yang, Chia-Jui Du, Hsiu‐Ju Yen, Meng-Ju Li, C W Lee, Phooi-Theng Liew, Dong-Tsamn Lin, Kai-Hsin Lin
+2 more S C Lin, Shiann‐Tarng Jou
DOI: 10.1182/bloodadvances.2025018288
Cited by: 1
References: 48

Abstract

ABSTRACT: Central nervous system (CNS) status in pediatric acute lymphoblastic leukemia (ALL) is a key prognostic factor that makes precise detection critical. Flow cytometry (FCM) offers a higher detection rate than conventional cytomorphology (CC); however, results are considered negative with

Fields of Study & Subjects

Acute Lymphoblastic Leukemia research Acute Myeloid Leukemia Research CNS Lymphoma Diagnosis and Treatment

Publication details

Journal / source
Blood Advances
Publisher
American Society of Hematology
Volume
10
Issue
10
Pages
3505–3516
Publication date
20 February 2026
Language
EN