Tidal breathing nasal nitric oxide measurement as a test for primary ciliary dyskinesia in young children

European Respiratory Journal 2026

View at publisher
Authors: Margaret W. Leigh, Adam Shapiro, Kunal K. Chawla, Milan J. Hazucha, David E. Brown, Feng‐Chang Lin, Li Jiang, Johnny L. Carson, Stephanie D. Davis, Sharon D. Dell, Scott D. Sagel, Margaret Rosenfeld
+5 more Carlos Milla, Kelli M. Sullivan, Maimoona A. Zariwala, Thomas Ferkol, Michael R. Knowles
DOI: 10.1183/13993003.01540-2025
Cited by: 2
References: 38

Abstract

BACKGROUND: Nasal nitric oxide (nNO) measurement during velum closure is a useful test for primary ciliary dyskinesia (PCD) but is not feasible in young children. Measurement during tidal breathing is an alternative approach. Our objectives were to define a protocol with age-specific cut-off nNO values during tidal breathing and evaluate this method as an adjunctive test for PCD. METHODS: A standardised method for nNO measurement during tidal breathing was developed and tested at the University of North Carolina in children aged

Fields of Study & Subjects

Cystic Fibrosis Research Advances Sinusitis and nasal conditions Delphi Technique in Research

Publication details

Journal / source
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Volume
67
Issue
6
Pages
2501540–2501540
Publication date
29 January 2026
Language
EN